La proteina de suero mejora la diabetes

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La proteina de suero mejora la diabetes

Notapor Fisio » Dom, 13 Jul 2014, 20:14

El suero disminuye los niveles de glucosa en sangre. Paper financiado pero cuadra con lo publicado antes.

Diabetologia. 2014 Jul 10. [Epub ahead of print]
Incretin, insulinotropic and glucose-lowering effects of whey protein pre-load in type 2 diabetes: a randomised clinical trial.
Jakubowicz D1, Froy O, Ahrén B, Boaz M, Landau Z, Bar-Dayan Y, Ganz T, Barnea M, Wainstein J.
Author information
Abstract
AIMS/HYPOTHESIS:

Since protein ingestion is known to stimulate the secretion of glucagon-like peptide-1 (GLP-1), we hypothesised that enhancing GLP-1 secretion to harness its insulinotropic/beta cell-stimulating activity with whey protein pre-load may have beneficial glucose-lowering effects in type 2 diabetes.
METHODS:

In a randomised, open-label crossover clinical trial, we studied 15 individuals with well-controlled type 2 diabetes who were not taking any medications except for sulfonylurea or metformin. These participants consumed, on two separate days, 50 g whey in 250 ml water or placebo (250 ml water) followed by a standardised high-glycaemic-index breakfast in a hospital setting. Participants were randomised using a coin flip. The primary endpoints of the study were plasma concentrations of glucose, intact GLP-1 and insulin during the 30 min following meal ingestion.
RESULTS:

In each group, 15 patients were analysed. The results showed that over the whole 180 min post-meal period, glucose levels were reduced by 28% after whey pre-load with a uniform reduction during both early and late phases. Insulin and C-peptide responses were both significantly higher (by 105% and 43%, respectively) with whey pre-load. Notably, the early insulin response was 96% higher after whey. Similarly, both total GLP-1 (tGLP-1) and intact GLP-1 (iGLP-1) levels were significantly higher (by 141% and 298%, respectively) with whey pre-load. Dipeptidyl peptidase 4 plasma activity did not display any significant difference after breakfast between the groups.
CONCLUSIONS/INTERPRETATION:

In summary, consumption of whey protein shortly before a high-glycaemic-index breakfast increased the early prandial and late insulin secretion, augmented tGLP-1 and iGLP-1 responses and reduced postprandial glycaemia in type 2 diabetic patients. Whey protein may therefore represent a novel approach for enhancing glucose-lowering strategies in type 2 diabetes. Trial registration ClinicalTrials.gov NCT01571622 Funding The Israeli Ministry of Health and Milk Council funded the research.


http://www.ncbi.nlm.nih.gov/pubmed/25005331
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Fisio
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Re: La proteina de suero mejora la diabetes

Notapor Icok » Lun, 14 Jul 2014, 21:33

Mmm pero si toman metformina como no les va a bajar....
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Re: La proteina de suero mejora la diabetes

Notapor Fisio » Lun, 28 Jul 2014, 03:19

Icok escribió:Mmm pero si toman metformina como no les va a bajar....


Pero se trata de que obtienes mejor control de la glucosa en el grupo fármaco + suero vs fármaco + placebo.
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Registrado: Dom, 01 Sep 2013, 14:18


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