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Grasa saturada sin relación con mortalidad en paciente coronario

Publicado: Sab, 07 Feb 2015, 20:28
por Fisio
Dietary Intake of Saturated Fat Is Not Associated with Risk of Coronary Events or Mortality in Patients with Established Coronary Artery Disease

Background: Data from recent meta-analyses question an association between dietary intake of saturated fatty acids (SFAs) and risk of cardiovascular disease (CVD). Moreover, the prognostic effect of dietary SFA in patients with established CVD treated with modern conventional medication has not been extensively studied.

Objective: We investigated the associations between self-reported dietary SFA intake and risk of subsequent coronary events and mortality in patients with coronary artery disease (CAD).

Methods: This study included patients who participated in the Western Norway B-Vitamin Intervention Trial and completed a 169-item semiquantitative food-frequency questionnaire after coronary angiography. Quartiles of estimated daily intakes of SFA were related to risk of a primary composite endpoint of coronary events (unstable angina pectoris, nonfatal acute myocardial infarction, and coronary death) and separate secondary endpoints (total acute myocardial infarction, fatal coronary events, and all-cause death) with use of Cox-regression analyses.

Results: This study included 2412 patients (81% men, mean age: 61.7 y). After a median follow-up of 4.8 y, a total of 292 (12%) patients experienced at least one major coronary event during follow-up. High intake of SFAs was associated with a number of risk factors at baseline. However, there were no significant associations between SFA intake and risk of coronary events [age- and sex-adjusted HR (95% CI) was 0.85 (0.61, 1.18) for the upper vs. lower SFA quartile] or any secondary endpoint. Estimates were not appreciably changed after multivariate adjustments.

Conclusions: There was no association between dietary intake of SFA and incident coronary events or mortality in patients with established CAD.
http://jn.nutrition.org/content/early/2 ... 5.abstract

Re: Grasa saturada sin relación con mortalidad en paciente coronario

Publicado: Mar, 10 Feb 2015, 11:42
por nick74
¿Qué te parece este artículo Fisio? : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2943062/

Re: Grasa saturada sin relación con mortalidad en paciente coronario

Publicado: Mar, 10 Feb 2015, 12:50
por Fisio
La primera frase ya hace daño a la vista
Despite the well-established observation that substitution of saturated fats for carbohydrates or unsaturated fats increases low-density lipoprotein (LDL) cholesterol in humans and animal models, the relationship of saturated fat intake to risk for atherosclerotic cardiovascular disease in humans remains controversial.

Si va a justificar un paper a partir de un surrogate (LDL) para mí es un ejemplo paradigmático de lo que no se debe hacer en ciencia. Vamos, es que siempre pongo ejemplos así.

Re: Grasa saturada sin relación con mortalidad en paciente coronario

Publicado: Vie, 13 Feb 2015, 01:01
por ZeRaTuL
Falta un "remains controversial for blind scientists and physicians who doesn't want to admit his errors".

Igualmente el estudio de Fisio no lo considero el mejor, dado que:
"[...] and completed a 169-item semiquantitative food-frequency questionnaire after coronary angiography...".

Food-frequency questionnaire sux. Pero no creo que las grasas saturadas causen arterioesclerosis. O no he visto estudios duros que lo demuestren.

Re: Grasa saturada sin relación con mortalidad en paciente coronario

Publicado: Vie, 13 Feb 2015, 15:28
por Fisio
Sí, si son los mismos cuestionarios que usaron para proponer todo tipo de teorías. O valen para todos o para ninguno.