Mucuna Pruriens

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Mucuna Pruriens

Notapor Fisio » Mié, 04 Sep 2013, 00:40

Mucuna Pruriens: ciencia, experiencias y marcas
Código de descuento Iherb JUY782

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Re: Mucuna Pruriens

Notapor Fisio » Sab, 04 Ene 2014, 22:43

Para enfermedad de parkinson y parkinsonimos parece incluso más efectivo que la farmacología

A water extract of Mucuna pruriens provides long-term amelioration of parkinsonism with reduced risk for dyskinesias.
Lieu CA, Kunselman AR, Manyam BV, Venkiteswaran K, Subramanian T.

Department of Neurology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.

Abstract
Dopaminergic anti-parkinsonian medications, such as levodopa (LD) cause drug-induced dyskinesias (DID) in majority of patients with Parkinson's disease (PD). Mucuna pruriens, a legume extensively used in Ayurveda to treat PD, is reputed to provide anti-parkinsonian benefits without inducing DID. We compared the behavioral effects of chronic parenteral administration of a water extract of M. pruriens seed powder (MPE) alone without any additives, MPE combined with the peripheral dopa-decarboxylase inhibitor (DDCI) benserazide (MPE+BZ), LD+BZ and LD alone without BZ in the hemiparkinsonian rat model of PD. A battery of behavioral tests assessed by blinded investigators served as outcome measures in these randomized trials. In experiment 1, animals that received LD+BZ or MPE+BZ at high (6mg/kg) and medium (4mg/kg) equivalent doses demonstrated significant alleviation of parkinsonism, but, developed severe dose-dependent DID. LD+BZ at low doses (2mg/kg) did not provide significant alleviation of parkinsonism. In contrast, MPE+BZ at an equivalent low dose significantly ameliorated parkinsonism. In experiment 2, MPE without any additives (12mg/kg and 20mg/kg LD equivalent dose) alleviated parkinsonism with significantly less DID compared to LD+BZ or MPE+BZ. In experiment 3, MPE without additives administered chronically provided long-term anti-parkinsonian benefits without causing DID. In experiment 4, MPE alone provided significantly more behavioral benefit when compared to the equivalent dose of synthetic LD alone without BZ. In experiment 5, MPE alone reduced the severity of DID in animals initially primed with LD+BZ. These findings suggest that M. pruriens contains water-soluble ingredients that either have an intrinsic DDCI-like activity or mitigate the need for an add-on DDCI to ameliorate parkinsonism. These unique long-term anti-parkinsonian effects of a parenterally administered water extract of M. pruriens seed powder may provide a platform for future drug discoveries and novel treatment strategies in PD.


J Neurol Neurosurg Psychiatry. 2004 Dec;75(12):1672-7.

Mucuna pruriens in Parkinson's disease: a double blind clinical and pharmacological study.
Katzenschlager R, Evans A, Manson A, Patsalos PN, Ratnaraj N, Watt H, Timmermann L, Van der Giessen R, Lees AJ.

National Hospital for Neurology and Neurosurgery, London, UK.

Abstract
BACKGROUND: The seed powder of the leguminous plant, Mucuna pruriens has long been used in traditional Ayurvedic Indian medicine for diseases including parkinsonism. We have assessed the clinical effects and levodopa (L-dopa) pharmacokinetics following two different doses of mucuna preparation and compared them with standard L-dopa/carbidopa (LD/CD).

METHODS: Eight Parkinson's disease patients with a short duration L-dopa response and on period dyskinesias completed a randomised, controlled, double blind crossover trial. Patients were challenged with single doses of 200/50 mg LD/CD, and 15 and 30 g of mucuna preparation in randomised order at weekly intervals. L-dopa pharmacokinetics were determined, and Unified Parkinson's Disease Rating Scale and tapping speed were obtained at baseline and repeatedly during the 4 h following drug ingestion. Dyskinesias were assessed using modified AIMS and Goetz scales.

RESULTS: Compared with standard LD/CD, the 30 g mucuna preparation led to a considerably faster onset of effect (34.6 v 68.5 min; p = 0.021), reflected in shorter latencies to peak L-dopa plasma concentrations. Mean on time was 21.9% (37 min) longer with 30 g mucuna than with LD/CD (p = 0.021); peak L-dopa plasma concentrations were 110% higher and the area under the plasma concentration v time curve (area under curve) was 165.3% larger (p = 0.012). No significant differences in dyskinesias or tolerability occurred.

CONCLUSIONS: The rapid onset of action and longer on time without concomitant increase in dyskinesias on mucuna seed powder formulation suggest that this natural source of L-dopa might possess advantages over conventional L-dopa preparations in the long term management of PD. Assessment of long term efficacy and tolerability in a randomised, controlled study is warranted.


Neuroprotective effects of the antiparkinson drug Mucuna pruriens.
Manyam BV, Dhanasekaran M, Hare TA.
Author information
Abstract

Mucuna pruriens possesses significantly higher antiparkinson activity compared with levodopa in the 6-hydroxydopamine (6-OHDA) lesioned rat model of Parkinson's disease. The present study evaluated the neurorestorative effect of Mucuna pruriens cotyledon powder on the nigrostriatal tract of 6-OHDA lesioned rats. Mucuna pruriens cotyledon powder significantly increased the brain mitochondrial complex-I activity but did not affect the total monoamine oxidase activity (in vitro). Unlike synthetic levodopa treatment, Mucuna pruriens cotyledon powder treatment significantly restored the endogenous levodopa, dopamine, norepinephrine and serotonin content in the substantia nigra. Nicotine adenine dinucleotide (NADH) and coenzyme Q-10, that are shown to have a therapeutic benefit in Parkinson's disease, were present in the Mucuna pruriens cotyledon powder. Earlier studies showed that Mucuna pruriens treatment controls the symptoms of Parkinson's disease. This additional finding of a neurorestorative benefit by Mucuna pruriens cotyledon powder on the degenerating dopaminergic neurons in the substantia nigra may be due to increased complex-I activity and the presence of NADH and coenzyme Q-10.
Código de descuento Iherb JUY782

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Re: Mucuna Pruriens

Notapor Fisio » Dom, 05 Ene 2014, 21:17

Bueno, pues voy a probar 4-8 cápsulas de Now a ver que tal. En total 240-480 mg de L-dopa respectivamente. Ya contaré si noto algo.
Código de descuento Iherb JUY782

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Re: Mucuna Pruriens

Notapor jwarrior » Dom, 05 Ene 2014, 23:09

con algun fin en concreto? la L-dopa puede dar problemas a la larga.....
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Re: Mucuna Pruriens

Notapor Fisio » Dom, 05 Ene 2014, 23:25

jwarrior escribió:con algun fin en concreto? la L-dopa puede dar problemas a la larga.....


Como nootrópico. La mucuna no da tantos problemas como la levodopa, posiblemente el conjunto de nutrientes de la planta protegen de la toxicidad observada con el fármaco. De todos modos en el caso de que notase algo, solo sería para un uso ocasional.
Código de descuento Iherb JUY782

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Re: Mucuna Pruriens

Notapor jwarrior » Dom, 05 Ene 2014, 23:57

En otros post estabamos hablando de la dopamina y tal.... crees que lo notaras en la funcion sexual?
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Re: Mucuna Pruriens

Notapor Fisio » Lun, 06 Ene 2014, 10:24

jwarrior escribió:En otros post estabamos hablando de la dopamina y tal.... crees que lo notaras en la funcion sexual?


Es plausible, si noto algo lo cuento. De momento ayer 5 cápsulas a lo largo del día al 15% que son 300 mg de L-Dopa y no noté nada en ningún aspecto. Llegaré hasta 500 mg de L-Dopa y quizás debería juntar las tomas.
Código de descuento Iherb JUY782

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Re: Mucuna Pruriens

Notapor Fit » Lun, 06 Ene 2014, 13:12

¿Y lo mezclas con la crema de chocolate y cacahuete o cómo va esto?
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Re: Mucuna Pruriens

Notapor Fisio » Mié, 15 Ene 2014, 12:51

De momento dias sueltos con 360 mg de L-dopa no he notado nada. Subiré a 480 durante algunos días a ver. El problema de todo esto es que no hay afinidad específica por los núcleos dopaminérgicos
Código de descuento Iherb JUY782

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