La marihuana podría curar la epilepsia

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La marihuana podría curar la epilepsia

Notapor Fisio » Sab, 24 May 2014, 03:09

Madre reduce los ataques de epilepsia a su hija con marihuana: de 50 diarios a 2 al mes.

The case for medical marijuana in epilepsy

Summary

Charlotte, a little girl with SCN1A-confirmed Dravet syndrome, was recently featured in a special that aired on CNN. Through exhaustive personal research and assistance from a Colorado-based medical marijuana group (Realm of Caring), Charlotte's mother started adjunctive therapy with a high concentration cannabidiol/Δ9-tetrahydrocannabinol (CBD:THC) strain of cannabis, now known as Charlotte's Web. This extract, slowly titrated over weeks and given in conjunction with her existing antiepileptic drug regimen, reduced Charlotte's seizure frequency from nearly 50 convulsive seizures per day to now 2–3 nocturnal convulsions per month. This effect has persisted for the last 20 months, and Charlotte has been successfully weaned from her other antiepileptic drugs. We briefly review some of the history, preclinical and clinical data, and controversies surrounding the use of medical marijuana for the treatment of epilepsy, and make a case that the desire to isolate and treat with pharmaceutical grade compounds from cannabis (specifically CBD) may be inferior to therapy with whole plant extracts. Much more needs to be learned about the mechanisms of antiepileptic activity of the phytocannabinoids and other constituents of Cannabis sativa.


http://onlinelibrary.wiley.com/doi/10.1 ... 946.f02t03

CBD appears to be an ideal candidate among phytocannabinoids as a therapy for treatment-resistant epilepsy

http://onlinelibrary.wiley.com/doi/10.1 ... 5/abstract

Cannabidiol: Pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders

Summary

To present a summary of current scientific evidence about the cannabinoid, cannabidiol (CBD) with regard to its relevance to epilepsy and other selected neuropsychiatric disorders. We summarize the presentations from a conference in which invited participants reviewed relevant aspects of the physiology, mechanisms of action, pharmacology, and data from studies with animal models and human subjects. Cannabis has been used to treat disease since ancient times. Δ9-Tetrahydrocannabinol (Δ9-THC) is the major psychoactive ingredient and CBD is the major nonpsychoactive ingredient in cannabis. Cannabis and Δ9-THC are anticonvulsant in most animal models but can be proconvulsant in some healthy animals. The psychotropic effects of Δ9-THC limit tolerability. CBD is anticonvulsant in many acute animal models, but there are limited data in chronic models. The antiepileptic mechanisms of CBD are not known, but may include effects on the equilibrative nucleoside transporter; the orphan G-protein-coupled receptor GPR55; the transient receptor potential of vanilloid type-1 channel; the 5-HT1a receptor; and the α3 and α1 glycine receptors. CBD has neuroprotective and antiinflammatory effects, and it appears to be well tolerated in humans, but small and methodologically limited studies of CBD in human epilepsy have been inconclusive. More recent anecdotal reports of high-ratio CBD:Δ9-THC medical marijuana have claimed efficacy, but studies were not controlled. CBD bears investigation in epilepsy and other neuropsychiatric disorders, including anxiety, schizophrenia, addiction, and neonatal hypoxic-ischemic encephalopathy. However, we lack data from well-powered double-blind randomized, controlled studies on the efficacy of pure CBD for any disorder. Initial dose-tolerability and double-blind randomized, controlled studies focusing on target intractable epilepsy populations such as patients with Dravet and Lennox-Gastaut syndromes are being planned. Trials in other treatment-resistant epilepsies may also be warranted.


http://onlinelibrary.wiley.com/doi/10.1 ... 1/abstract
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Re: La marihuana podría curar la epilepsia

Notapor gpg » Lun, 26 May 2014, 21:22

Fisio escribió:Madre reduce los ataques de epilepsia a su hija con marihuana: de 50 diarios a 2 al mes.

The case for medical marijuana in epilepsy

Summary

Charlotte, a little girl with SCN1A-confirmed Dravet syndrome, was recently featured in a special that aired on CNN. Through exhaustive personal research and assistance from a Colorado-based medical marijuana group (Realm of Caring), Charlotte's mother started adjunctive therapy with a high concentration cannabidiol/Δ9-tetrahydrocannabinol (CBD:THC) strain of cannabis, now known as Charlotte's Web. This extract, slowly titrated over weeks and given in conjunction with her existing antiepileptic drug regimen, reduced Charlotte's seizure frequency from nearly 50 convulsive seizures per day to now 2–3 nocturnal convulsions per month. This effect has persisted for the last 20 months, and Charlotte has been successfully weaned from her other antiepileptic drugs. We briefly review some of the history, preclinical and clinical data, and controversies surrounding the use of medical marijuana for the treatment of epilepsy, and make a case that the desire to isolate and treat with pharmaceutical grade compounds from cannabis (specifically CBD) may be inferior to therapy with whole plant extracts. Much more needs to be learned about the mechanisms of antiepileptic activity of the phytocannabinoids and other constituents of Cannabis sativa.


http://onlinelibrary.wiley.com/doi/10.1 ... 946.f02t03

CBD appears to be an ideal candidate among phytocannabinoids as a therapy for treatment-resistant epilepsy

http://onlinelibrary.wiley.com/doi/10.1 ... 5/abstract

Cannabidiol: Pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders

Summary

To present a summary of current scientific evidence about the cannabinoid, cannabidiol (CBD) with regard to its relevance to epilepsy and other selected neuropsychiatric disorders. We summarize the presentations from a conference in which invited participants reviewed relevant aspects of the physiology, mechanisms of action, pharmacology, and data from studies with animal models and human subjects. Cannabis has been used to treat disease since ancient times. Δ9-Tetrahydrocannabinol (Δ9-THC) is the major psychoactive ingredient and CBD is the major nonpsychoactive ingredient in cannabis. Cannabis and Δ9-THC are anticonvulsant in most animal models but can be proconvulsant in some healthy animals. The psychotropic effects of Δ9-THC limit tolerability. CBD is anticonvulsant in many acute animal models, but there are limited data in chronic models. The antiepileptic mechanisms of CBD are not known, but may include effects on the equilibrative nucleoside transporter; the orphan G-protein-coupled receptor GPR55; the transient receptor potential of vanilloid type-1 channel; the 5-HT1a receptor; and the α3 and α1 glycine receptors. CBD has neuroprotective and antiinflammatory effects, and it appears to be well tolerated in humans, but small and methodologically limited studies of CBD in human epilepsy have been inconclusive. More recent anecdotal reports of high-ratio CBD:Δ9-THC medical marijuana have claimed efficacy, but studies were not controlled. CBD bears investigation in epilepsy and other neuropsychiatric disorders, including anxiety, schizophrenia, addiction, and neonatal hypoxic-ischemic encephalopathy. However, we lack data from well-powered double-blind randomized, controlled studies on the efficacy of pure CBD for any disorder. Initial dose-tolerability and double-blind randomized, controlled studies focusing on target intractable epilepsy populations such as patients with Dravet and Lennox-Gastaut syndromes are being planned. Trials in other treatment-resistant epilepsies may also be warranted.


http://onlinelibrary.wiley.com/doi/10.1 ... 1/abstract


Descubierto un mecanismo por el que el abuso de cannabis puede causar esquizofrenia

http://www.csic.es/web/guest/home?p_p_i ... tType=news
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Re: La marihuana podría curar la epilepsia

Notapor Fisio » Lun, 26 May 2014, 21:31

gpg escribió:Descubierto un mecanismo por el que el abuso de cannabis puede causar esquizofrenia

http://www.csic.es/web/guest/home?p_p_i ... tType=news


Un titular desmedido para una simple hipótesis. En el propio texto hablan explícitamente de un abuso y en menores. Hay evidencia suficiente para desaconsejar el consumo de cannabis en menores. En mayores, tendría que mirar a fondo los estudios, pero probablemente la asociación entre consumo de cannabis y la esquizofrenía posiblemente se explica por causalidad inversa en gran parte. No es que el consumo de cannabis provoque esquizofrenia. Sino que las personas predispuestas a la esquizofrenia, al tener tendencias estresoras y rasgos más o menos subclínicos de distinta psicopatología, tienden a consumir marihuana para automedicarse. De ahí la asociación entre consumo de marihuana y esquizofrenia, y prácticamente todos los tipos de desadaptaciones y trastornos psíquicos.

Por si alguien no lo entiende, pongo otro ejemplo. La gente con sobrepeso consume light. Pero el light no causó necesariamente su sobrepeso, sino que al verse con sobrepeso, decidieron consumir light. Pero ya estaban gordos antes, en realidad fue el estar gordo lo que causó el consumo de comida light y no al revés. Lo mismo con el cannabis y con las drogas en general. Muchos consumidores ya tenían principios de problemas psicopatológicos antes sin diagnosticar, y por eso consumen todo tipo de historias.
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Re: La marihuana podría curar la epilepsia

Notapor Cobayahumana » Jue, 03 Jul 2014, 10:50

¿Esquizofrenia? osea que hay un duelo interno entre lo que se QUIERE hacer y lo que los demás te han dicho que DEBES hacer... claro... esquizofrénico...

Un tio que escucha sus propias voces... la marihuana te activa el lóbulo del ensueño nada màs, la esquizofrenia la tiene quien no ha puesto ORDEN en su vida y todavia está DISOCIADO....es una bicefalia... el tipico angel y el diablillo que cada uno te dice lo contrario y no sabes a quien hacerle caso...

Es como cuando soñamos, quiza algun dia diagnostiquen de enfermedad patológica a aquellos que recuerden sus sueños, ya que estarán atentando contra las normas si acaso sueñan asesinar gente... desde luego en occidente hay una epidemia de estupidez que creo que es lo único que nos tiene amargados.

Remedios contra la estupidez, vence tus miedos y veras que no existian, que eras un espejo de lo que querias ser... tyler durden o edward norton... miraos el club de la lucha... dejad de pegaros tiros a vosotros mismos, no lo vais a poder matar nunca... porque no existe... son solo las ilusiones auto creadas...identificadas en un personaje o un malvado exterior, ya sea el sistema, una persona concreta, o determinadas actitudes que considerais nocivas porque en el fondo hay algún miedo...

Yo por mi parte he dejado la adicción a la marihuana, llevo desde el dia 9 que ingresé hasta hoy dia 3 sin probar ni una calada, basicamente he ordenado mi vida y no necesito fumar, aparte que para dormir tomo serotonina y zinc y magnesio... y se acabó.... todo mi problema se llamaba INSOMNIO... asi cualquiera se disocia...

vosotros dormis o descansais? hay una diferencia clara entre ambos conceptos...la marihuana ayuda a descansar, como la serotonina... tambien a ensoñar... los que tienen miedo de estas sustancias tienen miedo a sus deseos porque son los que se manifiestan al tomarlas... tal como cuando soñamos profundamente....
El mejor traje que puedes llevar es la desnudez.

https://www.facebook.com/ManuCulturismoAmateur
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Re: La marihuana podría curar la epilepsia

Notapor Fisio » Jue, 16 Oct 2014, 21:09

Ya están con un fármaco. Pero que listos son.

Nuevo medicamento a base de marihuana podría salvar a niños con epilepsia

Texto completo en: http://actualidad.rt.com/ciencias/view/ ... -epilepsia

http://actualidad.rt.com/ciencias/view/ ... -epilepsia
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Re: La marihuana podría curar la epilepsia

Notapor Carne » Mar, 03 Nov 2015, 18:08

La cetosis también lo hace
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